Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig
نویسندگان
چکیده
منابع مشابه
Protective effect of neurotrophic agent T-817MA against inner ear barotrauma in the guinea pig.
T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer's disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotra...
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OBJECTIVES/HYPOTHESIS Scuba diving may cause severe hearing loss and vertigo due to inner ear barotrauma and decompression sickness. These may be difficult to differentiate clinically. Decompression sickness requires costly and potentially dangerous hyperbaric therapy, whereas such treatment may worsen barotrauma. The objective of this study was to assess the potential utility of magnetic reson...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2011
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.11033sc